Cellzilla2D performs xCellerator simulations on two-dimensional tissue objects. Each cell is treated as a separate polygonal compartment. The tissue object itself consists of three parts: a list of vertex coordinates; a list of edges, composed of integer pairs of vertex numbers; and a list of cells consisting of integer lists of edge numbers. Tissues may be defined externally by the user, or one of a collection of preddfined templates may be used. For an annotated example see: [html or Zipped Mathematica Notebook].

Cellzilla2D models are compatible with CelleratorML and CellzillaML, XML-based file formats for transferring models. Cellzilla models can also be saved to SBML using xlr8r2sbml.

Stochastic models can be simulated using xSSA (under development).